Rice is an important crop used as a staple food in most of the world; however the occurrence of pests is increasing due to climate change. In particular, the brown planthopper (BPH, Nilaparvata lugens stal) is a key cause of rice yield loss. In response to the era of unpredictable climate change in the future, the Plant Molecular Breeding laboratory of the Department of Applied Biosciences, Graduate School, Kyungpook National University, Daegu 41566, Korea bred the ‘Drimi2ho’ strain, which is resistance to BPH or various pests and of excellent eating quality. In order to cultivate ‘Drimi2ho’, ‘Samgang’ and ‘Nagdong’ were crossed and the derived seeds were backcrossed with ‘Junam’, and the pedigree breeding method was applied. During the application of the pedigree method, agricultural characteristics which are investigated in the field were found to be excellent, and the best line for various disease resistance, grain quality, and yield was finally selected as ‘Drimi2ho’. ‘Drimi2ho’ has strong resistance to BPH and its range of resistance to major pests and viral diseases such as blast and bacterial blight on rice is quite wide. In the field, the main agricultural characteristics of ‘Drimi2ho’ were similar to or improved from those of ‘Junam’. ‘Drimi2ho’ is a cultivar with enhanced disease and pest resistance and a wide spectrum while maintaining the good eating quality. ‘Drimi2ho’ yielded 584 kg/10a in ordinary cultivation under normal level of fertilization in south mid-mountainous areas of Korea. Drimi2ho’ can thus be a standard cultivar in Korea due to its varied resistance to multiple diseases and excellent grain quality. (Registration No. 4686).